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1 Potential explanations for the therapeutic effect of propranolol — a nonselective beta-blocker — on infantile capillary hemangiomas include vasoconstriction, which is immediately visible as a change in color, associated with a palpable softening of the hemangioma; decreased expression of VEGF and bFGF genes through the down-regulation of the RAF–mitogen-activated protein kinase pathway 4 (which explains the progressive improvement of the hemangioma); and the triggering of apoptosis of capillary endothelial cells.

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